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How should I take tolvaptan?

You will receive your first dose in a hospital or clinic setting to quickly treat any serious side effects.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Long-term use of tolvaptan can damage your liver or cause death. You should not use tolvaptan for longer than 30 days.
You may take tolvaptan with or without food.
Take Samsca with a full glass (8 ounces) of water. Drink plenty of fluids during the first 24 hours of taking tolvaptan, but avoid alcoholic drinks. Follow your doctor's instructions about the type and amount of liquids you should drink while treating hyponatremia.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to serious side effects.
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Store at room temperature away from moisture and heat.
If you stop taking tolvaptan for any length of time, do not start taking it again at home. You will need to be in a hospital under observation any time you start or restart treatment with tolvaptan.

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