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Do not take Zanaflex with any of the following medications:

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  • clonidine
  • fluvoxamine
  • guanabenz
  • guanfacine
  • methyldopa

Zanaflex may also interact with the following medications:

  • acyclovir
  • alcohol
  • antihistamines
  • baclofen
  • barbiturates like phenobarbital
  • benzodiazepines
  • cimetidine
  • famotidine
  • female hormones, like estrogens or progestins and birth control pills
  • medicines for high blood pressure
  • medicines for irregular heartbeat
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  • medicines for sleep
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This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

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