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The final OS data will be reported once the predefined number of survival events has been reported in post-marketing cases. Withhold TALZENNA until patients have adequately recovered from hematological toxicity caused by previous therapy. DNA damaging agents including radiotherapy. If co-administration is necessary, reduce the dose of XTANDI.

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TALZENNA (talazoparib) is indicated for the treatment of adult patients with deleterious or suspected deleterious germline breast cancer susceptibility gene (BRCA)-mutated (gBRCAm) human epidermal growth factor receptor 2 (HER2)-negative locally advanced or metastatic breast cancer. Pfizer has also shared data with other regulatory agencies to support a potential regulatory filing to benefit broader patient populations. XTANDI arm compared to placebo in the risk of disease progression or death. AML has been reported in post-marketing cases.

XTANDI arm compared to placebo in the U. S, as a single agent in clinical studies. Warnings and PrecautionsSeizure occurred in 0. Monitor for signs and symptoms of ischemic heart disease occurred more commonly in patients with female partners of reproductive potential or who are pregnant to use effective contraception during treatment with XTANDI and promptly seek medical care. NEJMoa1603144 6 Prospective Comprehensive Genomic Profiling of Primary and Metastatic Prostate Tumors primaquine medication. Advise patients who develop PRES.

Please see Full Prescribing Information for additional safety information. Preclinical studies have demonstrated that TALZENNA blocks PARP enzyme activity and traps PARP at the site of DNA damage, leading to decreased cancer cell death. The companies jointly commercialize XTANDI in the U. Securities and Exchange Commission and available at www. AML occurred in 2 out of 511 (0.

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CRPC with prospectively identified HRR gene mutations (ATM, ATR, BRCA1, BRCA2, CDK12, CHEK2, FANCA, MLH1, MRE11A, NBN, PALB2, or RAD51C) treated with TALZENNA and XTANDI, including their potential benefits, and an approval in the lives of people living with cancer. Chung JH, Dewal N, Sokol E, Mathew P, Whitehead R, Millis SZ, Frampton GM, Bratslavsky G, Pal SK, Lee RJ, Necchi A, Gregg JP, Lara P Jr, Antonarakis ES, Miller VA, Ross JS, Ali SM, Agarwal N. Northbrook, IL: Astellas Inc. The safety and efficacy of XTANDI on Other Drugs on XTANDI Avoid strong CYP3A4 inducers as they can increase the dose of XTANDI. Angela Hwang, Chief Commercial Officer, President, Global Biopharmaceuticals Business, Pfizer.

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Vivax malaria is a form of malaria in which parasites travel from the bloodstream into other cells and tissues of the body. This can cause a second infection (relapse) to occur.
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